Zhengdeng Lei, PhD

Zhengdeng Lei, PhD

2009 - Present Research Fellow at Duke-NUS, Singapore
2007 - 2009 High Throughput Computational Analyst, Memorial Sloan-Kettering Cancer Center, New York
2003 - 2007 PhD, Bioinformatics, University of Illinois at Chicago

Monday, October 31, 2011

GSM2Sample.pl

use lib 'E:/perl_lib';
use FileSystem;

my $work_dir = 'E:\CEL\GSE15460\GSE15460_RAW\GSE15460.SG.CEL';
my $output_file = 'E:\CEL\GSE15460\GSE15460_RAW\GSE15460.info.txt';

my @CellFiles = ();
@CellFiles = FileSystem::GetFileByPattern($work_dir, '\.CEL', @CellFiles);
foreach $cel (@CellFiles)
{
print "$cel\n";
my @CELContent = FileSystem::ReadFile($cel);
my $sample_info_line = $CELContent[13];
my @sample_info = split(/[\s:]/, $sample_info_line);
print "$sample_info[2]";

FileSystem::WriteFile($output_file, "$cel\t$sample_info[2]\n");


}

FileSystem::Close();


STANDARD TRID Tumors on mRNA (Affy U133P2) Reason for exclusion GEO NGCII011/LGE GC-011LGE-T.CEL Fail QC GSM387788.CEL NGCII035/PCC GC-035PCC-T.CEL Fail QC GSM387797.CEL NGCII038/LYC GC-038LYC-T.CEL Fail QC GSM387798.CEL TGCII021/LAH GC-021LAH-T.CEL Fail QC GSM387790.CEL 980327 GC-980327T.CEL called as "adenosquamous cancer", relapse also adenosquamous GSM387937.CEL 2000619 GC-2000619T.CEL squamous CA GSM387844.CEL TGCII026/GJK GC-026-GJK-T.CEL GIST/squamous GSM387793.CEL TGCII039/TSC GC-039-TSC-T.CEL GIST/squamous GSM387799.CEL

幽门螺杆菌(Hp)感染、肠上皮化生、萎缩性胃炎

幽门螺杆菌(Hp)感染、肠上皮化生、萎缩性胃炎

Wednesday, October 26, 2011

Sunday, October 16, 2011

BFRM+NTP

top 1/3 vs bottom 1/3
use NTP and gene signature to predict the direction.

Thursday, October 13, 2011

human gastric precancerous lesions

http://www.weibing.com.cn/html/mxqbxwy/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766652/pdf/v045p000I5.pdf
http://www.google.com.sg/url?sa=t&source=web&cd=2&ved=0CC0QFjAB&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1146204%2F&ei=yNuWTtO4BsLsrAeSvqWbBA&usg=AFQjCNHwRAwFh8ipHDTFVBzNx-r7G-dbkg&sig2=kbm6v1zThHgCqzhCMyg13Q


chronic superficial gastritis (CSG, 16),
chronic atrophic gastritis (CAG, 16), intestinal metaplasia
(IM, 35), gastric epithelial dysplasia (GED, 23) and gastric
cancer (CA, 25), and conditions of H.pylori infection

Tuesday, October 11, 2011

http://en.wikipedia.org/wiki/Carcinogenesis

A new way of looking at carcinogenesis comes from integrating the ideas of developmental biology into oncology. The cancer stem cell hypothesis proposes that the different kinds of cells in a heterogeneous tumor arise from a single cell, termed Cancer Stem Cell. Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist as a subcomponent of the tumor and retain key stem cell properties. They give rise to a variety of cells, are capable of self-renewal and homeostatic control.[25]Furthermore, the relapse of cancer and the emergence of metastasis are also attributed to these cells. The cancer stem cell hypothesis does not contradict earlier concepts of carcinogenesis.
A new way of looking at carcinogenesis comes from integrating the ideas of developmental biology into oncology. The cancer stem cell hypothesis proposes that the different kinds of cells in a heterogeneous tumor arise from a single cell, termed Cancer Stem Cell. Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist as a subcomponent of the tumor and retain key stem cell properties. They give rise to a variety of cells, are capable of self-renewal and homeostatic control.[25]Furthermore, the relapse of cancer and the emergence of metastasis are also attributed to these cells. The cancer stem cell hypothesis does not contradict earlier concepts of carcinogenesis.