BFRM+NTP

top 1/3 vs bottom 1/3
use NTP and gene signature to predict the direction.

human gastric precancerous lesions

http://www.weibing.com.cn/html/mxqbxwy/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766652/pdf/v045p000I5.pdf
http://www.google.com.sg/url?sa=t&source=web&cd=2&ved=0CC0QFjAB&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1146204%2F&ei=yNuWTtO4BsLsrAeSvqWbBA&usg=AFQjCNHwRAwFh8ipHDTFVBzNx-r7G-dbkg&sig2=kbm6v1zThHgCqzhCMyg13Q


chronic superficial gastritis (CSG, 16),
chronic atrophic gastritis (CAG, 16), intestinal metaplasia
(IM, 35), gastric epithelial dysplasia (GED, 23) and gastric
cancer (CA, 25), and conditions of H.pylori infection

http://en.wikipedia.org/wiki/Carcinogenesis

A new way of looking at carcinogenesis comes from integrating the ideas of developmental biology into oncology. The cancer stem cell hypothesis proposes that the different kinds of cells in a heterogeneous tumor arise from a single cell, termed Cancer Stem Cell. Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist as a subcomponent of the tumor and retain key stem cell properties. They give rise to a variety of cells, are capable of self-renewal and homeostatic control.^[25]Furthermore, the relapse of cancer and the emergence of metastasis are also attributed to these cells. The cancer stem cell hypothesis does not contradict earlier concepts of carcinogenesis.

A new way of looking at carcinogenesis comes from integrating the ideas of developmental biology into oncology. The cancer stem cell hypothesis proposes that the different kinds of cells in a heterogeneous tumor arise from a single cell, termed Cancer Stem Cell. Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a body. These cells persist as a subcomponent of the tumor and retain key stem cell properties. They give rise to a variety of cells, are capable of self-renewal and homeostatic control.^[25]Furthermore, the relapse of cancer and the emergence of metastasis are also attributed to these cells. The cancer stem cell hypothesis does not contradict earlier concepts of carcinogenesis.

http://www.pnas.org/content/101/3/811.full

http://www.pnas.org/content/101/3/811.full

http://www.cancer.gov/cancertopics/understandingcancer/cancergenomics

http://www.cancer.gov/cancertopics/understandingcancer/cancergenomics

http://www.cancer.gov/cancertopics/understandingcancer/moleculardiagnostics