The neoplastic grading is a measure of cell anaplasia (lack of differentiation) in the sampled tumor and is based on the resemblance of the tumor to the tissue of origin.
Anaplasia refers to a reversion of differentiation in cells and is characteristic of malignant neoplasms (tumors). Sometimes, the term also includes an increased capacity for multiplication.[1] Lack of differentiation is considered a hallmark of aggressive malignancies. The term anaplasia literally means "to form backward". It implies dedifferentiation, or loss of structural and functional differentiation of normal cells. It is now known, however, that at least some cancers arise from stem cells in tissues; in these tumors failure of differentiation, rather than dedifferentiation of specialized cells, account for undifferentiated tumors.
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