Normalization before NTP

Before NTP, is it better to do standardization on gene(row) then on array(column) to avoid population bias.
Or may median polish (an iterative method)?

ANSWER: It is NOT GOOD to do standardization on gene(row) then on array(column) to avoid population bias.


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# standardization by row and column, respetively
#By row (gene)
std.data.by.row <- t(scale(t(data.filtered), scale=T))
#By column (array)
std.data <- scale(std.data.by.row, scale=T)